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Day (United States of America)A Brief Overview
Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.
CHOP's Commitment to Diversity, Equity, and Inclusion
CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.
We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.
Responsibilities
* Participate in project planning, recording, and evaluation of data.
* Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator).
* Acquire technical, lab management, and grant writing skills.
* Participate in seminars, lectures, poster sessions, national presentations, and professional workshops.
* Supervise junior lab members.
* Assist with other research projects as needed.
Education Qualifications
- Doctorate (required)
About the Laboratory
A postdoctoral position is available for studying mechanisms of skeletal development, metabolism and repair at The Children's Hospital of Philadelphia (CHOP). The lab seeks to elucidate the molecular characteristics and fate determination of mesenchymal stem and progenitor cells in bone, and to understand the role of cellular and systemic metabolism in skeletal health and diseases. The experimental techniques include transcriptomic or epigenomic profiling by high throughout sequencing, molecular biology, mouse genetics and quantitative metabolic assays. The researcher will have access to first-rate core facilities both at CHOP and University of Pennsylvania, and enjoy interactions with experts in the fields of skeletal biology and metabolism at both institutions. An ideal candidate should have PhD or equivalent research experience in cell, molecular or developmental biology with a strong motivation for musculoskeletal research.
Current research topics include the following.
-Skeletal stem and progenitor cells: The human skeleton is built and maintained by stem and progenitor cells but the identity, location, and control of those cells in the body remain incompletely understood. Ongoing projects aim to track and manipulate those cells genetically by using scRNA-seq and lineage-tracing techniques in animal models.
-Bone metabolism in type I or type II diabetes: Both juvenile and adult diabetes are associated with increased bone fractures. Current studies are uncovering the cellular and molecular basis for the bone frailty in diabetic mouse models, with the goal of discovering new therapeutic targets.
-Skeletal aging: Osteoarthritis and osteoporosis are commonly related with aging, but current treatments are inadequate. Current projects are exploring the connection between changes in cellular metabolism and skeletal health during aging.
Additional information is available on websites:
Please direct inquiry or application to Professor Fanxin Long, longf1@chop.edu.
Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.