Summary

The Thathiah laboratory in the Department of Neurobiology at the University of Pittsburgh School of Medicine is looking for two highly motivated postdoctoral associates who are passionate about neuroscience and disease-related research. The lab is broadly interested in studying the molecular and cellular mechanisms underlying the pathophysiology of Alzheimer's Disease (AD). The positions are ideal for individuals who wish to work in a highly collaborative environment utilizing human-derived induced neuronal (iN) and glial models to answer hypothesis-driven questions and translate in vitro findings to pre-clinical murine models of AD.

Description and Responsibilities

The first postdoctoral scholar will lead an NIH-funded project to investigate the mechanisms involved in neuroimmune communication in AD. Recently, we determined that a G protein-coupled-receptor (GPCR), GPR3, is abundantly expressed in glia, which may trigger a neuroprotective response to the accumulation of AD pathology. The second postdoctoral scholar will lead a project to investigate the mechanisms involved in the pathological phosphorylation and aggregation of tau utilizing an optogenetic model of tau aggregation (optoTAU) that was recently developed in the lab, which provides a platform to investigate molecular and cellular modifiers of tau aggregation.

The lab utilizes a multidisciplinary approach, combining genetically engineered mouse and cell culture models along with molecular, cellular, and biochemical techniques to study the etiology of AD. We continuously strive to implement novel cutting-edge technology in the lab, allowing for timely investigation of AD-relevant biological questions. The long-term goal of our studies is to uncover disease mechanisms and to develop alternate avenues for therapeutic intervention. We believe that basic scientific discoveries will steer the course toward effective treatments for AD.

Qualifications and Faculty Expectations

• A recent Ph.D. and strong publication record in neuroscience, biology, biochemistry, or related field. Sterile tissue culture and/or IPSC experience is required. Proficiency with molecular biology techniques, e.g., RNA isolation and cloning, is required. Experience with biochemical approaches, e.g., protein isolation and Western blot analysis, is required. Experience with confocal microscopy is required. Experience with immunocytochemistry and immunohistochemistry is preferred. Experience with single-cell, whole genome, and proteomic analysis is preferred. Experience with mouse handling, including injection, dissection, and behavioral approaches is preferred. Excellent verbal and written communication skills, technical expertise, and scientific creativity are essential.

Interested postdoctoral candidates should send a brief statement of research accomplishments and future interests, contact information for three references, and a CV to requisition #24000533 using this link .

The University of Pittsburgh provides a comprehensive career development program through the Office of Academic Career Development (OACD). The OACD is dedicated to enhancing the academic success of biomedical scientists by offering a range of programs, from an Annual Postdoctoral Data & Dine Symposium, which offers postdoctoral associates the opportunity to present their research to colleagues and faculty while networking with attendees, to career development and essential professional skills series, which focus on career options, professional development workshops, and how to prepare for the next career steps. In addition, the Center for Postdoctoral Affairs in Health Sciences offers A Developmental Approach to Professional Training (ADAPT), which provides a framework for postdoctoral associates to align their professional development efforts with the appropriate stage of their training.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity, and diversity. EOE, including disability/vets.